Exercise-induced oxidative stress is a well-documented phenomenon characterized by increased production of reactive oxygen species (ROS), leading to tissue damage and inflammation. Vitamin D3, known for its diverse physiological roles, has emerged as a potential mitigator of oxidative stress due to its antioxidant properties. This review explores the mechanisms through which Vitamin D3 modulates oxidative stress pathways during exercise. Key mechanisms include the regulation of antioxidant enzyme activity, reduction of lipid peroxidation, and modulation of inflammatory responses. Clinical studies investigating the effects of Vitamin D3 supplementation on markers of oxidative stress post-exercise are examined, highlighting its potential as a protective agent against exercise-induced tissue damage. Further research is warranted to elucidate optimal dosing strategies and its broader implications in enhancing exercise recovery and overall health.

Vitamin D3, Exercise, Oxidative Stress

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