International Journal of Medical Science and Public Health Research

Assessment Of Hemodynamic And Homeostatic Effects Of Unilateral Spinal Anesthesia During Joint Replacement Surgery Of The Lower Extremities In Elderly Patients

2025-11-12T08:00:25+00:00

Unilateral spinal anesthesia with a low dose of hyperbaric bupivacaine is a safe and effective analgesic technique for elderly patients with high cardiovascular risk undergoing lower limb joint replacement. The method ensures hemodynamic stability, minimal metabolic alterations, and a high safety profile.

Longitudinal Retinal Imaging In Stage IV-A Retinopathy Of Prematurity: A Case Series On Disease Progression And Management

2025-11-01T13:28:26+00:00

Background: Retinopathy of Prematurity (ROP) is a leading cause of childhood blindness, with advanced stages like Stage IV-A presenting significant management challenges. While wide-field retinal imaging has revolutionized ROP screening, its utility in monitoring the detailed evolution of the disease, particularly in advanced stages, is not extensively documented. This study aims to illustrate the longitudinal progression of Stage IV-A ROP using serial retinal imaging.

Methods: This retrospective case series was conducted at a tertiary neonatal care center. Premature infants diagnosed with Stage IV-A ROP who underwent serial examinations with a wide-field infant retinal camera were included. A comprehensive review of their medical records and sequential retinal images was performed. The evolution of key pathological features, including the extent of retinal detachment, vascular abnormalities, and ridge characteristics, was documented and correlated with clinical management decisions.

Results: The case series details the clinical and imaging journey of infants with Stage IV-A ROP. The longitudinal images provided a dynamic view of the disease, revealing subtle yet critical changes in the retinal detachment and vascular activity that influenced the timing and choice of interventions, including laser photocoagulation and vitreoretinal surgery. The imaging data served as an objective tool for monitoring treatment response and guiding subsequent management steps.

Conclusion: Serial wide-field retinal imaging is an indispensable tool for the nuanced management of Stage IV-A ROP. It provides crucial, objective insights into disease dynamics that surpass traditional examinations, facilitating more precise and timely clinical decision-making. The integration of such technology into standard care protocols is vital for improving outcomes in this vulnerable population.

Association Of Allelic Polymorphisms Of Pro-Inflammatory Cytokine Genes With The Severity Of Immune Microthrombovasculitis

2025-11-04T08:11:34+00:00

Purpose of the study: To assess the role of the polymorphic variant of the TNF-α gene (rs1800629) VEGFA (rs2010963) in the development of a severe course of immune microthrombovasculitis.

Material and methods: The study included 75 patients with IMTV (main group) aged 16 to 80 years and 73 conditionally healthy individuals (comparison group) without pathology of the hemostasis system, comparable in age and gender with the main group. Detection of polymorphic variants of genes TNF-α (rs 1800629) and VEGFA (rs2010963) was carried out by SNP-PCR.

Results and discussion: Differences in the frequency of occurrence of the mutant genotype of the mutant genotype G/G (χ2>3.84; P<0.05) of the polymorphic variant of the VEGFA gene (rs2010963) were established depending on the severity of IMTV, which allows clinicians to determine it as a genetic predictor of severe disease.