ISSN: 2767-3774
editor@ijmsphr.com
Articles 2024-02-15 Peer Reviewed

ANTI-RADICAL AND MEMBRANE-ACTIVE PROPERTIES OF GERANIIN POLYPHENOL COMPOUND

Dildora Rahmatullaevna Isamukhamedova • Nurali Azamovich Ergashev • Rahmatilla Nurullaevich Rakhimov • Muzaffar Islamovich Asrarov
Dimensions Research discovery

Authors

  • Dildora Rahmatullaevna Isamukhamedova
    Institute of Biophysics and Biochemistry under the National University of Uzbekistan, Tashkent, Uzbekistan
  • Nurali Azamovich Ergashev
    Institute of Biophysics and Biochemistry under the National University of Uzbekistan, Tashkent, Uzbekistan
  • Rahmatilla Nurullaevich Rakhimov
    Institute of Bioorganic Chemistry of the Academy of Sciences of the Republic of Uzbekistan, Tashkent, Uzbekistan
  • Muzaffar Islamovich Asrarov
    Institute of Biophysics and Biochemistry under the National University of Uzbekistan, Tashkent, Uzbekistan

Keywords

Geraniin polyphenol anti-radical properties membrane-active

Abstract

This research paper explores the anti-radical and membrane-active properties of geraniin polyphenol compound. Through experimentation, it was found that geraniin polyphenol exhibits a stabilizing effect on mitochondrial functional parameters and inhibits TssA-sensitive Sa2+-dependent mitochondrial megapore. Furthermore, the compound activates the permeability of the liver mitoK ATF channel and demonstrates membranotropic properties by regulating the size of the matrix. Notably, geraniin polyphenol showcases robust antiradical properties, indicating potent antioxidant activity. These findings shed light on the multifaceted pharmacological potential of geraniin polyphenol and its prospective applications in mitigating oxidative stress-related disorders.

Downloads

Download data is not yet available.

References

1
Almeida AM ., Bertoncini CR . Mitochondrial DNA damage associate with lipid peroxidation of the mitochondrial membrane induced by Fe2+- citrate // An . Acad . Bras . Cienc . 2006. 78. p.505-514.
2
Andrews D. T., Royce C. , Royce A. G. The mitochondrial permeability transition pore and its role in anesthesia-triggered cellular protection during ischemia-reperfusion injury // Anaesth Intensive Care. - 2012 . – Vol. 40(1) . - P. 46-70.
3
Brand MC, David GN Assessing mitochondrial dysfunction in cells// Biochem . J. -2011.-V. 435 - R. 297–312.
4
Briston T., Selwood D. L. , Szabadkai G. , Duchene M. R. Mitochondrial permeability transition: a molecular lesion with multiple drug targets // Trends Pharmacol Sci. - 2019 . - Vol. 40(1) . p. 50-70.
5
Hagai R., Hoek JB The mitochondrial permeability transition: nexus of aging, disease and longevity// Cells 2021 . V 10. R . 79.
6
6 . Molino S., Francino MP, Henares JA Why is it important to understand the nature and chemistry of tannins to exploit their potential as nutraceuticals ?/ / Food research international –2023. - V 173. p.1-18.
7
Moronkola DO; Adesanwo JK; Aiyelaagbe OO and Faruq UZ Essential Oil Composition of Three Compositae - Aspillia africana , Chromolaena odorata , Syndrella nodiflora and One Labiatae - Hyptis suaveolens Utilized as Rabbit Feeds. // Journal of Scientific Research – 2013. V–12, p 327-344
8
Szewczyk A., Bednarczyk P., JędraszkoJ., Kampa RP, Koprowski P., Krajewska M., Kucman Sh., Kulawiak B., Laskowski M., Rotko D., Sęk A., Walewska A., Żochowska M. ., Wrzosek A. Mitochondrial potassium channels – an overview// Postepy Biochemii –2018. -V 64. -R. 2-3.
9
Rao V. K. , Carlson E. A. , Yan S. S. Mitochondrial permeability transition pore is a potential drug target for neurodegeneration // BBA. - 2014 . - Vol. 1842(8) . - P. 1267-1272.
10
Umegaki T. , Okimura Y. , Fujita H. , that is, H. , Akiyama J. , Inoue M. , Utsumi K. , Sasaki J. Flow cytometric analysis of Ca-induced membrane permeability transition of isolated rat liver mitochondria // J Clin Biochem Nutr. - 2008. - Vol. 42(1) . - P. 35-44.
11
Javadov S. , Hunter J. C., Barreto-Torres G . , Parodi-Rullan R. Targeting the mitochondrial permeability transition: cardiac ischemia-reperfusion versus carcinogenesis // Cell Physiol Biochem. - 2011 . - Vol. 27(3-4) . - P. 179-190.
12
Smeriglio A., Barreca D., Bellocco E., Trombetta D. Proanthocyanidins and hydrolysable tannins: occurrence, dietary intake and pharmacological effects// British journal of pharmacology. -2017. - V 174. - R. 1244–1262.
13
Schneider WC, Hogeboom GH Cytochemical studies of mammalian tissues: the isolation of cell components by differential centrifugation// Cancer. Res . -1951. - V. _ 11(1). - P. 1-22.
14
Vadzyuk O.B., Kosterin S.A. Diazoxide-induced swelling of rat myometrial mitochondria as evidence of activation of the ATP-sensitive K channel // Ukr. biochem. magazine -2008. -T. 80(5). From 45-50
15
Kachaeva E.V. Mitochondrial ATP-sensitive potassium channel and its role in the body’s adaptation to hypoxia // –2007. Author's abstract. dis. Ph.D. biol.
16
Martinovich T.G., Cherenkevich S.N. Redox homeostasis of cells//Belarusian state university –2008. – V 39. –R. 29-44.
17
Zadnipryany I.V., Tretyakova O.S., Kubyshkin A.V., Sataeva T.P. Cardioprotective effect of domestic antihypoxants in experimental cobalt cardiomyopathy // Bulletin of Siberian Medicine, –2016. –V 15. –R. 33–40.