Articles | Open Access |

ANTI-RADICAL AND MEMBRANE-ACTIVE PROPERTIES OF GERANIIN POLYPHENOL COMPOUND

Dildora Rahmatullaevna Isamukhamedova , Institute of Biophysics and Biochemistry under the National University of Uzbekistan, Tashkent, Uzbekistan
Nurali Azamovich Ergashev , Institute of Biophysics and Biochemistry under the National University of Uzbekistan, Tashkent, Uzbekistan
Rahmatilla Nurullaevich Rakhimov , Institute of Bioorganic Chemistry of the Academy of Sciences of the Republic of Uzbekistan, Tashkent, Uzbekistan
Muzaffar Islamovich Asrarov , Institute of Biophysics and Biochemistry under the National University of Uzbekistan, Tashkent, Uzbekistan

Abstract

This research paper explores the anti-radical and membrane-active properties of geraniin polyphenol compound. Through experimentation, it was found that geraniin polyphenol exhibits a stabilizing effect on mitochondrial functional parameters and inhibits TssA-sensitive Sa2+-dependent mitochondrial megapore. Furthermore, the compound activates the permeability of the liver mitoK ATF channel and demonstrates membranotropic properties by regulating the size of the matrix. Notably, geraniin polyphenol showcases robust antiradical properties, indicating potent antioxidant activity. These findings shed light on the multifaceted pharmacological potential of geraniin polyphenol and its prospective applications in mitigating oxidative stress-related disorders.

Keywords

Geraniin polyphenol, anti-radical properties, membrane-active

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Dildora Rahmatullaevna Isamukhamedova, Nurali Azamovich Ergashev, Rahmatilla Nurullaevich Rakhimov, & Muzaffar Islamovich Asrarov. (2024). ANTI-RADICAL AND MEMBRANE-ACTIVE PROPERTIES OF GERANIIN POLYPHENOL COMPOUND. International Journal of Medical Science and Public Health Research, 5(02), 17–23. Retrieved from https://ijmsphr.com/index.php/ijmsphr/article/view/103