HUMAN ERYTHROCYTES AS PRAVASTATIN CARRIERS: A CHARACTERIZATION STUDY

Omar Badawi

Authors

Omar Badawi

Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia

Keywords

Erythrocytes Red Blood Cells Pravastatin

Abstract

The exploration of human erythrocytes (red blood cells) as biocompatible carriers for drug delivery offers promising advancements in targeted therapeutics. This study investigates the feasibility of utilizing erythrocytes as carriers for pravastatin, a commonly used statin for cholesterol management. In vitro methodologies were employed to load pravastatin into erythrocytes, followed by comprehensive characterization of the loading efficiency, encapsulation stability, and release profile. Erythrocyte morphology, membrane integrity, and hemoglobin release were monitored post-loading to assess potential cytotoxic effects. Findings indicate that erythrocytes effectively encapsulate pravastatin with high efficiency, maintain structural stability, and enable a controlled release over an extended period. The results highlight human erythrocytes as a potential drug delivery platform for pravastatin, potentially enhancing its bioavailability and reducing systemic side effects. Further research is needed to optimize loading protocols and confirm in vivo efficacy.

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