1
Salje, H.; Kiem, C.T.; Lefrancq, N.; Courtejoie, N.; Bosetti, P.; Paireau, J.; Andronico, A.; Hozé, N.; Richet, J.; Dubost, C.-L.; et al. Estimating the Burden of SARS-CoV-2 in France. Science 2020, 369, 208–211. [Google Scholar] [CrossRef] [PubMed]
2
Romanello, M.; Napoli, C.D.; Green, C.; Kennard, H.; Lampard, P.; Scamman, D.; Walawender, M.; Ali, Z.; Ameli, N.; Ayeb-Karlsson, S.; et al. The 2023 Report of the Lancet Countdown on Health and Climate Change: The Imperative for a Health-Centred Response in a World Facing Irreversible Harms. Lancet 2023, 402, 2346–2394. [Google Scholar] [CrossRef]
3
de Souza, F.R.; Motta-Santos, D.; dos Santos Soares, D.; de Lima, J.B.; Cardozo, G.G.; Guimarães, L.S.P.; Negrão, C.E.; dos Santos, M.R. Association of Physical Activity Levels and the Prevalence of COVID-19-Associated Hospitalization. J. Sci. Med. Sport 2021, 24, 913–918. [Google Scholar] [CrossRef] [PubMed]
4
Pinto, A.J.; Goessler, K.F.; Fernandes, A.L.; Murai, I.H.; Sales, L.P.; Reis, B.Z.; Santos, M.D.; Roschel, H.; Pereira, R.M.R.; Gualano, B. No Independent Associations between Physical Activity and Clinical Outcomes among Hospitalized Patients with Moderate to Severe COVID-19. J. Sport Health Sci. 2021, 10, 690–696. [Google Scholar] [CrossRef] [PubMed]
5
Sallis, R.; Young, D.R.; Tartof, S.Y.; Sallis, J.F.; Sall, J.; Li, Q.; Smith, G.N.; Cohen, D.A. Physical Inactivity Is Associated with a Higher Risk for Severe COVID-19 Outcomes: A Study in 48 440 Adult Patients. Br. J. Sports Med. 2021, 55, 1099–1105. [Google Scholar] [CrossRef]
6
Steenkamp, L.; Saggers, R.T.; Bandini, R.; Stranges, S.; Choi, Y.-H.; Thornton, J.S.; Hendrie, S.; Patel, D.; Rabinowitz, S.; Patricios, J. Small Steps, Strong Shield: Directly Measured, Moderate Physical Activity in 65,361 Adults Is Associated with Significant Protective Effects from Severe COVID-19 Outcomes. Br. J. Sports Med. 2022, 56, 568–576. [Google Scholar] [CrossRef]
7
Vanhelst, J.; Srour, B.; Bourhis, L.; Charreire, H.; VerdotDeschasaux-Tanguy, C.M.; Druesne-Pecollo, N.; De Edelenyi, F.S.; Allègre, J.; Allès, B.; Deschamps, V.; et al. Association of SARS-CoV-2 Infection with Physical Activity Domains and Types. Sci. Rep. 2023, 13, 19187. [Google Scholar] [CrossRef]
8
Tiku, V.; Tan, M.-W.; Dikic, I. Mitochondrial Functions in Infection and Immunity. Trends Cell Biol. 2020, 30, 263–275. [Google Scholar] [CrossRef]
9
Monlun, M.; Hyernard, C.; Blanco, P.; Lartigue, L.; Faustin, B. Mitochondria as Molecular Platforms Integrating Multiple Innate Immune Signalings. J. Mol. Biol. 2017, 429, 1–13. [Google Scholar] [CrossRef]
10
Balan, E.; Schwalm, C.; Naslain, D.; Nielens, H.; Francaux, M.; Deldicque, L. Regular Endurance Exercise Promotes Fission, Mitophagy, and Oxidative Phosphorylation in Human Skeletal Muscle Independently of Age. Front. Physiol. 2019, 10, 1088. [Google Scholar] [CrossRef]
11
Mayer, K.A.; Stöckl, J.; Zlabinger, G.J.; Gualdoni, G.A. Hijacking the Supplies: Metabolism as a Novel Facet of Virus-Host Interaction. Front. Immunol. 2019, 10, 1533. [Google Scholar] [CrossRef] [PubMed]
12
Nunn, A.V.W.; Guy, G.W.; Brysch, W.; Botchway, S.W.; Frasch, W.; Calabrese, E.J.; Bell, J.D. SARS-CoV-2 and Mitochondrial Health: Implications of Lifestyle and Ageing. Immun. Ageing 2020, 17, 33. [Google Scholar] [CrossRef] [PubMed]
13
Dyrstad, S.M.; Anderssen, S.A.; Edvardsen, E.; Hansen, B.H. Cardiorespiratory Fitness in Groups with Different Physical Activity Levels. Scand. Med. Sci. Sports 2016, 26, 291–298. [Google Scholar] [CrossRef]
14
Huang, G.; Wang, R.; Chen, P.; Huang, S.C.; Donnelly, J.E.; Mehlferber, J.P. Dose–Response Relationship of Cardiorespiratory Fitness Adaptation to Controlled Endurance Training in Sedentary Older Adults. Eur. J. Prev. Cardiolog. 2016, 23, 518–529. [Google Scholar] [CrossRef]
15
Yuan, Q.; Huang, H.; Chen, X.; Chen, R.; Zhang, Y.; Pan, X.; Chen, J.; Liu, N.; Du, H. Does Pre-Existent Physical Inactivity Have a Role in the Severity of COVID-19? Ther. Adv. Respir. Dis. 2021, 15, 175346662110252. [Google Scholar] [CrossRef]
16
Hamer, M.; Kivimäki, M.; Gale, C.R.; Batty, G.D. Lifestyle Risk Factors, Inflammatory Mechanisms, and COVID-19 Hospitalization: A Community-Based Cohort Study of 387,109 Adults in UK. Brain Behav. Immun. 2020, 87, 184–187. [Google Scholar] [CrossRef]
17
Craig, C.L.; Marshall, A.L.; Sjöström, M.; Bauman, A.E.; Booth, M.L.; Ainsworth, B.E.; Pratt, M.; Ekelund, U.; Yngve, A.; Sallis, J.F.; et al. International Physical Activity Questionnaire: 12-Country Reliability and Validity. Med. Sci. Sports Exerc. 2003, 35, 1381–1395. [Google Scholar] [CrossRef]
18
Silsbury, Z.; Goldsmith, R.; Rushton, A. Systematic Review of the Measurement Properties of Self-Report Physical Activity Questionnaires in Healthy Adult Populations: Figure 1. BMJ Open 2015, 5, e008430. [Google Scholar] [CrossRef]
19
Brown, W.J.; Trost, S.G.; Bauman, A.; Mummery, K.; Owen, N. Test-Retest Reliability of Four Physical Activity Measures Used in Population Surveys. J. Sci. Med. Sport 2004, 7, 205–215. [Google Scholar] [CrossRef]