Clinical and Pathogenetic Relationship Between Nephropathy and Diabetic Foot Syndrome

Saitov Dilshod Narzulloevic

doi:10.37547/ijmsphr/Volume06Issue05-05

Authors

Saitov Dilshod Narzulloevic

PhD, Assistant of the Department of General and Pediatric Surgery No1, Tashkent State Medical University, Tashkent, Uzbekistan

Keywords

Diabetes mellitus diabetic nephropathy diabetic foot syndrome chronic renal failure severity of complications.

Abstract

Diabetic nephropathy and diabetic foot syndrome are among the most severe and disabling complications of diabetes mellitus, determining the severity of systemic disorders and an unfavorable prognosis. Modern research indicates the presence of a common pathogenetic basis for these conditions, including chronic inflammation, endothelial dysfunction, microcirculation disorders and activation of fibrotic processes. In this work, data on 32 patients with various degrees of diabetic foot syndrome according to the Wagner classification, who simultaneously showed signs of diabetic nephropathy, are considered. The analysis showed that more severe forms of foot syndrome are associated with a pronounced decrease in the glomerular filtration rate and a high degree of albuminuria, which indicates progressive kidney damage in this category of patients. The data obtained emphasize the need for a comprehensive assessment of target organ damage in patients with diabetes mellitus, which is important both for the prognosis and for the choice of management tactics. Particular attention is paid to the role of chronic renal failure as a factor in the deterioration of reparative processes and a predisposition to purulent-necrotic complications of the lower extremities.

Downloads

Download data is not yet available.

References

1

National Kidney Foundation. KDOQI Clinical Practice Guideline for Diabetes and CKD: 2012 Update // Am J Kidney Dis. – 2012. – Vol. 60, № 5. – P. 850–886.

2

Tuttle K.R., Bakris G.L., Bilous R.W., et al. Diabetic kidney disease: a report from an ADA Consensus Conference // Diabetes Care. – 2014. – Vol. 37, № 10. – P. 2864–2883.

3

Navarro-González J.F., Mora-Fernández C. The role of inflammatory cytokines in diabetic nephropathy // J Am Soc Nephrol. – 2008. – Vol. 19, № 3. – P. 433–442.

4

American Diabetes Association. Standards of Medical Care in Diabetes – 2021 // Diabetes Care. – 2021. – Vol. 44, Suppl 1. – P. S125–S150.

5

Boulton A.J.M., Vileikyte L., Ragnarson-Tennvall G., Apelqvist J. The global burden of diabetic foot disease // Lancet. – 2005. – Vol. 366, № 9498. – P. 1719–1724.

6

Armstrong D.G., Boulton A.J.M., Bus S.A. Diabetic foot ulcers and their recurrence // N Engl J Med. – 2017. – Vol. 376, № 24. – P. 2367–2375.

7

Lipsky B.A., Berendt A.R., Cornia P.B., et al. 2012 Infectious Diseases Society of America clinical practice guideline for the diagnosis and treatment of diabetic foot infections // Clin Infect Dis. – 2012. – Vol. 54, № 12. – P. e132–e173.

8

Ndip A., Lavery L.A., Lafontaine J., Rutter M.K., Vardhan A., Boulton A.J.M. High levels of foot ulceration and amputation risk in a multiracial cohort of diabetic patients with nephropathy // Diabetes Care. – 2010. – Vol. 33, № 4. – P. 878–880.

9

Game F.L., Jeffcoate W.J. The role of neuropathy and ischemia in diabetic foot ulceration // Int J Low Extrem Wounds. – 2012. – Vol. 11, № 2. – P. 111–116.

10

Hingorani A., LaMuraglia G.M., Henke P., et al. The management of diabetic foot: a clinical practice guideline by the Society for Vascular Surgery // J Vasc Surg. – 2016. – Vol. 63, № 2 Suppl. – P. 3S–21S.