CONSEQUENTIAL EFFECTS OF MATERNAL HYPOTHERMIA IN GESTATIONAL DIABETIC RATS: INDUCTION OF OXIDATIVE CHANGES IN OFFSPRING BRAIN

Rizwan Mahaboob

doi:10.37547/ijmsphr/Volume04Issue01-03

Authors

Rizwan Mahaboob

Medical Intern, Jawaharlal Nehru Medical College, Belagavi, Karnataka, India

Keywords

Maternal hypothermia gestational diabetes oxidative stress

Abstract

This study examines the consequential effects of maternal hypothermia in gestational diabetic rats on oxidative changes in the brain of their offspring. Maternal hypothermia and gestational diabetes are both known to have adverse effects on offspring health, but their combined impact on oxidative stress in the brain remains poorly understood. Using a rat model, we induced diabetes in pregnant rats and exposed them to hypothermia during gestation. Offspring brains were assessed for oxidative changes through the measurement of oxidative markers. Our findings reveal a significant induction of oxidative changes in the brains of offspring exposed to maternal hypothermia in the presence of gestational diabetes. These changes suggest potential long-term neurodevelopmental implications for offspring. Further research is warranted to elucidate the underlying mechanisms and explore potential interventions to mitigate the consequences of maternal hypothermia and gestational diabetes on offspring brain health.

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