The problem of identifying and treating mycoses in otorhinolaryngology is gaining great importance not only because of their increasingly widespread distribution. This is due to the fact that fungal infections of the upper respiratory tract and ear are more severe than other inflammatory processes in this localization and can be the primary focus of visceral mycosis or cause sepsis, especially in childhood. An increase in the incidence of mycoses, infection and superinfection with fungi often contribute to the transition of acute processes into chronic ones, the occurrence of relapses and a more severe course of the disease. Delayed diagnosis and irrational treatment can lead to the generalization of a fungal infection, which is especially severe.

Otomycosis, fungal infection, otitis

Jia X., Liang Q., Chi F., Cao W. Otomycosis in Shanghai. Aetiology , clinical features and therapy. Mycoses . 2012; 55 (5): 404-409. doi.org/10.1111/j.1439-0507. 2011.02132.x

Klimko N.N. Diagnosis and treatment of modern mycoses: modern recommendations; Bulletin of the Northwestern State Medical University named after. I. _ I. _ Mechnikova , 2010.

Kiselev A.B., Chaukina V.A. Study of the clinical effectiveness of candibiotic ear drops for the treatment of acute external and otitis media. Herald otorhinolaryngology . 2013; 6: 76-78.

Vasilyeva N.V., Klimko N.N., Tsinzerling V.A. Diagnosis and treatment of invasive mycoses: modern recommendations; Bulletin of the North-Western State Medical University named after. I. _ I. _ Mechnikova , 2010.

Kryukov A.I., Kunelskaya V.Ya., Shadrin G.B. Mycotic lesions of the ENT organs. Medicinal matter . 2011.

Smagulova G.A. Mycotic diseases of the ENT organs in outpatient practice. Medicine And ecology . 2012

Asilbekova Zh.A. Modern methods of treating fungal diseases of the ENT organs. Herald surgery Kazakhstan , 2012

Swain SK, Behera IC, Sahu MC, Das A. Povidone iodine soaked gelfoam for the treatment of recalcitrant otomycosis − Our experiences at a tertiary care teaching hospital of eastern India. Journal de Mycologie medicale . 2018; 28 (1): 122-127. doi.org/10.1016/j.mycmed.2017.11.006

Kryukov A.I., Kunelskaya N.L., Shadrin G.B. and others. The role of mycobiota in chronic inflammatory pathology of the ENT organs. Consilium Medicum . 2017; 19 (11): 52-56.

Okovity S.V., Ivkin D.Yu., Malygin S.V. Drug therapy for external and otitis media. Herald otorhinolaryngology . 2012; 1:52-56.

Palchun V.T., Ogorodnikov D.S. Experience in observation and treatment of patients with diffuse external otitis. Herald otorhinolaryngology . 2011; 2: 53-56.

Smirnova O., Litvak N. Skin mycoses: a promising infection. Remedium , 2015.

Mosikhin S. _ B. , Reschl L. _ I. _ And etc. _ Microflora of the ear canal in external otitis. Practical medicine. 2016; 2 (94): 18-23

Adobrin K.D., N'Gattia V.K., Kuadio-Yapo G.K. and others. Epidemiology of otomycosis at the Yopougon University Hospital (Abidjan, Côte d'Ivoire). MycologieMedical Journal . 2014; 24 (2): 9–15. doi.org/10.1016/j.mycmed.2013.07.057

Rao RP, Rao R. Mycological study of otomycosis in a tertiary care teaching hospital in Karnataka, India. International Journal of Contemporary Medical Research. 2016; 3(7): 1918–1920.

Eremeeva K.V. Mycoses in otorhinolaryngology: diagnosis, prevention, treatment. Medical council , 2016

Mosikhin S. _ B. _ And al . Review of classifications of external otitis from the standpoint of their optimization. Practical medicine, 2015

Ozturkkan S., Ozturkkan S. Dermatological diseases of the external ear. Dermatology clinics. 2014; 32 (1): 141–152. doi.org/10.1016/j.clindermatol.2013.05.036.

Li Y., He L. Diagnosis and treatment of otomycosis in South China. Mycoses. 2019; 62(11):1064–1068. doi.org/10.1111/myc.12979

Agarwal P., Devi L.S. Otomycosis in a rural community attending a tertiary care hospital: assessment of risk factors and identification of fungal and bacterial agents. Journal of Clinical and Diagnostic Research. 2017; 11 (6): DC14–DC18. doi : 10.7860/JCDR/2017/25865.10068

Narbaev K.P., Narbaev Z.K., Turgunov A.A. Some issues of otomycosis : clinical picture, diagnosis and modern methods of treatment. Innovative science No. 2, 2016

Probst R., Grevers G., Iro G. Otorhinolaryngology in clinical practice. M. , 2012: 384.

Dundar R., Ainen I.Y. in general Local use of a single dose of clotrimazole for the treatment of otomycosis : is it enough? Otol. 2019; 23 (1):15-19. doi : 10.7874/jao.2018.00276

Jimenez-Garcia L, Celis -Aguilar E, Diaz-Pavon G, et al. Efficacy of topical clotrimazole compared with topical tolnaftate in the treatment of otomycosis . Randomized controlled clinical trial. Brazilian Journal of Otorhinolaryngology. 2019; 18. doi.org/10.1016/j.bjorl.2018.12.007

Philip A, Thomas R, Job A, et al. Efficacy of 7.5% povidone-iodine versus 1% clotrimazole with lignocaine in the treatment of otomycosis , Otolaryngology. 2013. doi.org/10.1155/2013/239730.

Gerasim K., Bonaparte J.P., et al. Comparison of Locacorten-Vioform and clotrimazole in otomycosis : a systematic review and one-sided meta-analysis. Laryngoscope. 2016; 126(6):1411-9. doi : 10.1002/lary.25761

Stern Shavit S, Sudri E, Hamzani Y, Nageris B. Malignant otitis externa: factors predicting outcome. American Journal of Otolaryngology - Head and Neck Medicine and Surgery. 2016; 37 (5): 425–430. doi.org/10.1016/j.amjoto.2016.04.005

Hagiwara S, Tamura T, Sato K, et al. Molecular identification and antifungal susceptibility of Aspergillus species causing otomycosis in Tochigi, Japan. Mycopathology . 2019; 184 (1):13-21. doi.org/10.1007/s11046-018-0299-9

Svistushkin V.M., Sinkov E.V. Otitis externa: from differential diagnosis to etiotropic therapy. Medical council , 2016

Kamali Sarwestani H., Daie Ghazvini R., Hashemi S. J., et al. Otomycosis . Diagnosis and treatment. Clinics in dermatology. 2010; 28 (2): 202-211. doi . org /10.1016/ j . clindermatol .2009.12.003

Sapova K.I., Ryazantsev S.V. Topical therapy of external otitis of various etiologies. Medical Council, 2017. doi . org /10.21518/2079-701X - 2017-16-92-95

Yasin Merad , Hayat Ajmi-Hamoudi , Kader Lammer et al. Otomycosis in hearing aid users : a retrospective study from 2010 to 2015. Journal of Medical Mycology . 2016; 26 (1): 1-7. doi.org/10.1016/j.mycmed.2016.02.012

Huguenin A., Noel V., Rogez A., et al. Scedosporium apiospermum otitis complicated by a temporomandibular arthritis: a case report and mini-review. Mycopathology . 2015; 180 (3-4): 257-264. doi.org/10.1007/s11046-015-9911-4

Volosach O.S. Treatment of candidiasis: possibilities and prospects (literature review). Magazine Grodno state medical University , 2014

Mujeeb MMA, Chudiwal T.B., Salve A.P. et al. Comparative study of the rate of recovery with topical use of clotrimazole and povidone-iodine for superficial fungal skin infections. J. Evol . Res. Honey. Pharmacol . 2017; 3:10-14. Case ID: 53659709

Jimenez-Garcia L, Celis -Aguilar E, Diaz-Pavon G, et al. Efficacy of topical clotrimazole compared with topical tolnaftate in the treatment of otomycosis . Randomized controlled clinical trial. Braz. J. Otorhinolaryngol . 2020; 86. doi.org/10.1016/j.bjorl.2018.12.007

Kiakojori K, Jamnani NB, Khafri S, Omran SM. Evaluation of response to treatment in patients with otomycosis . Iranian Journal of Otorhinolaryngology. 2018; 30, (96): 41-47. PMCID: PMC5787654, PMID: 29387663

Metin A., Dilek N., Demirseren D.D. Fungal infections of folds (intertriginous areas). Klin . Dermatol . 2015; 33(4):437–447. doi.org/10.1016/j.clindermatol.2015.04.005

Kim Y.-H. Clinical features of otomycosis , combined with chronic otitis media and pathogenic fungi. Journal of Mycology and Infections. 2018; 23 (4): 105–110. doi.org/10.17966/jmi.2018.23.4.105

Omran S.M., Yousefzadeh Z., Khafri S., et al. Effect of combination therapy with ceftizoxime and clotrimazole in the treatment of otomycosis . Modern medical mycology. 2018; 4 (1): 18-23. doi.org/10.18502/cmm.4.1.30

Dorasala S.P., Dorasala S. Medicinal gel foam for the treatment of resistant otomycosis . Indian Journal of Otology. 2013; 19 (1): 18-19. doi.org/10.4103/0971-7749.108155

Poojitha B, Kiran M. Review of otomycosis . Research Journal of Pharmaceutical, Biological and Chemical Sciences. 2016; 7 (3): 319–322.

Kiakojuri K., Rajabnia R., Mahdavi Omran S. et al. The role of clotrimazole in the prevention of recurrent otomycosis . Biomed Res Int. 2019; 26:32-35. doi.org/10.1155/2019/5269535

Dundar R., Ainen I. Topical use of a single dose of clotrimazole for the treatment of otomycosis : is it enough? Journal of Audiology and Otology. 2019; 23 (1): 15-19. doi.org/10.7874/jao.2018.00276

Xu S, Li J, Ding L, et al. Efficacy and safety of terbinafine hydrochloride spray and boric acid-alcohol ear drops for otomycosis . Acta Otolaryngol . 2020; 5:1-5. doi.org/10.1080/00016489.2020.1712474

Yang T.H., Yang Y.H. Eradication of otomycosis with terbinafine solution : basic and clinical studies. Audiol . Neurotol . 2019; 24 (4): 183–190. doi.org/10.1159/000501540

Vennewald I., Klemm E. Otomycosis : diagnosis and treatment. Klin . Dermatol . 2010; 28(2):202–211. doi.org/10.1007/s001060050003

Bassiouni A., Kamel T., Moawad M.K. and others. Broad-spectrum antifungal agents for otomycosis . J. Laryngol Otol. 1986; 100(8):867-873. doi.org/10.1017/S0022215100100246

Magliocca KR, Vivas ES, Griffith SS. Idiopathic, infectious and reactive lesions of the ear and temporal bone. Pathology of the head and neck. 2018; 12 (3): 328–349. doi.org/10.1007/s12105-018-0952-0