Brucellosis is a zoonotic infection that poses significant health challenges globally, particularly in regions with limited resources. Effective treatment depends on identifying the antimicrobial susceptibility profiles of Brucella spp. across various clinical specimens. This study aimed to compare the antimicrobial susceptibilities of Brucella isolates obtained from diverse clinical sources, including blood, bone marrow, cerebrospinal fluid, and other tissue samples. A total of [insert sample size] isolates were tested using [specify testing method, e.g., broth microdilution, disc diffusion] to determine their susceptibility to commonly prescribed antibiotics, such as doxycycline, rifampin, ciprofloxacin, and streptomycin. The results revealed [summarize key findings, e.g., differences in susceptibility profiles across specimen types, resistance trends]. The data highlight the importance of targeted antimicrobial therapy based on specimen-specific resistance patterns to improve patient outcomes in brucellosis treatment. This study contributes valuable insights into antimicrobial resistance trends in Brucella spp., underscoring the need for continuous surveillance and individualized treatment strategies in brucellosis management.

Brucella, Antimicrobial susceptibility, Clinical specimens

Pappas G, Papadimitriou P, Akritidis N, Christou L, Tsianos EV. The new global map of human brucellosis. Lancet Infect Dis. 2006; 6:91–99.

Young EJ. Brucella species. In: Mandell GL, Bennett JE, Dolin R, eds. Principles and practice of infectious diseases, 6th ed. Philadelphia: Churchill Livingstone; 2005: 2669–2672.

Black TF. Brucellosis. In: Cohen J, Powderly WG, eds. Infectious diseases; 2nd ed. St Louis: Mosby; 2004: 1665–1667.

Doğanay M, Meşe-Alp E. In: Topçu AW, Söyletir G, Doganay M, eds. Infeksiyon hastalıkları ve mikrobiyolojisi; 3rd ed. Istanbul: Nobel Tıp Kitabevleri; 2008: 897–909.

Yüce A, Alp-Çavuş S. Türkiye’de bruselloz: genel bakış. Klimik derg 2006; 19:87–97.

Ceylan E, Irmak H, Buzgan T, Karahocagil MK, Evirgen Ö, Sakarya N, et al. Van iline bağlı bazı köylerde insan ve hayvan populasyonunda bruselloz seroprevalansı. Van Tıp Derg. 2003; 10:1–5.

Joint Food and Agriculture Organization/World Health Organization. FAO–WHO Expert Committee on Brucellosis (sixth report). WHO Technical Report Series No. 740. Geneva: World Health Organisation; 1986: 56–57.

Baykam N, Esener H, Ergonul O, Eren S, Celikbas AK, Dokuzoguz B. In vitro antimicrobial susceptibility of Brucella species. Intern J Antimicrob Agents. 2004; 23:405-407.