The association between hypercholesterolemia and atopic dermatitis (AD) remains a subject of increasing clinical interest due to the shared pathways of systemic inflammation. This study examines 70 patients aged 16 to 60 with elevated blood cholesterol levels (220–350 mg/dL) to investigate the relationship between cholesterol levels and AD severity. Patients were stratified into two groups based on age: those under 40 (48 patients) and those over 40 (22 patients). Results revealed that hypercholesterolemia was more prevalent in older patients, while younger patients exhibited more severe forms of AD, ranging from mild eczema to severe atopic dermatitis. The findings suggest that age plays a critical role in the interplay between lipid metabolism and the inflammatory processes underlying AD, highlighting the importance of lipid monitoring in managing AD severity. Further research is needed to elucidate the mechanisms linking hypercholesterolemia and atopic inflammation.

Hypercholesterolemia, Atopic Dermatitis, Inflammation

J.H. Leigh, H.J. Park, S.M. Chun, Y.S. Min, M. Choi, Association of Atopic Dermatitis with Dyslipidemia in Adolescents: A Cross-Sectional Study, Ann Dermatol 33(5) (2021) 483-485.

S. Weidinger, N. Novak, Atopic dermatitis, Lancet 387(10023) (2016) 1109-1122.

D.A. Bulger, S. Minhas, A.A. Asbeutah, S. Kayali, H.A.K. Shirwany, J.R. Patel, M.P. Seitz, K. Clark, T. Patel, R.N. Khouzam, Chronic Systemic Inflammatory Skin Disease as a Risk Factor for Cardiovascular Disease, Current Problems in Cardiology 46(5) (2021) 100799.

C. Kern, C. Ortiz, M. Johanis, M. Ye, P. Tahir, A. Mulick, I.E. Allen, C.E. McCulloch, S.M. Langan, K. Abuabara, Atopic Dermatitis and Cardiovascular Risk in Pediatric Patients: A Systematic Review and Meta-Analysis, J Invest Dermatol 144(5) (2024) 1038-1047.e16.

C. Garcia, C.J. Andersen, C.N. Blesso, The Role of Lipids in the Regulation of Immune Responses, Nutrients 15(18) (2023).

J. Kim, B.E. Kim, D.Y.M. Leung, Pathophysiology of atopic dermatitis: Clinical implications, Allergy Asthma Proc 40(2) (2019) 84-92.

M. Böhme, Å. Svensson, I. Kull, C.-F. Wahlgren, Hanifin's and Rajka's minor criteria for atopic dermatitis: Which do 2-year-olds exhibit?, Journal of the American Academy of Dermatology 43(5) (2000) 785-792.

M.J. Rothe, J.M. Grant-Kels, Diagnostic criteria for atopic dermatitis, The Lancet 348(9030) (1996) 769-770.

R. Markovič, V. Grubelnik, H.B. Vošner, P. Kokol, M. Završnik, K. Janša, M. Zupet, J. Završnik, M. Marhl, Age-Related Changes in Lipid and Glucose Levels Associated with Drug Use and Mortality: An Observational Study, J Pers Med 12(2) (2022).

H.J. Jung, D.H. Lee, M.Y. Park, J. Ahn, Cardiovascular comorbidities of atopic dermatitis: using National Health Insurance data in Korea, Allergy, Asthma & Clinical Immunology 17(1) (2021) 94.

L. Maintz, T. Bieber, H.D. Simpson, A.L. Demessant-Flavigny, From Skin Barrier Dysfunction to Systemic Impact of Atopic Dermatitis: Implications for a Precision Approach in Dermocosmetics and Medicine, J Pers Med 12(6) (2022).

A. Trompette, N.D. Ubags, Skin barrier immunology from early life to adulthood, Mucosal Immunology 16(2) (2023) 194-207.

L.A. Beck, M.J. Cork, M. Amagai, A. De Benedetto, K. Kabashima, J.D. Hamilton, A.B. Rossi, Type 2 Inflammation Contributes to Skin Barrier Dysfunction in Atopic Dermatitis, JID Innov 2(5) (2022) 100131.

T. Çetinarslan, L. Kümper, R. Fölster-Holst, The immunological and structural epidermal barrier dysfunction and skin microbiome in atopic dermatitis-an update, Front Mol Biosci 10 (2023) 1159404.

A.C. Chong, K. Visitsunthorn, P.Y. Ong, Genetic/Environmental Contributions and Immune Dysregulation in Children with Atopic Dermatitis, J Asthma Allergy 15 (2022) 1681-1700.

J.M. Biagini Myers, G.K. Khurana Hershey, Eczema in early life: genetics, the skin barrier, and lessons learned from birth cohort studies, J Pediatr 157(5) (2010) 704-14.

R.G. Reed, S.R. Presnell, A. Al-Attar, C.T. Lutz, S.C. Segerstrom, Life stressors and immune aging: Protective effects of cognitive reappraisal, Brain, Behavior, and Immunity 110 (2023) 212- 221.