RESULTS OF VEGF-A CYTOKINES IN ACUTE SENSONEURAL HEARING LOSS OF VARIOUS GENESIS

U.S. Khasanov; U.P. Abdullaev

Authors

U.S. Khasanov

Tashkent Medical Academy, Uzbekistan
U.P. Abdullaev

Tashkent Medical Academy, Uzbekistan

Keywords

Cytokine sensorineural hearing loss steroid therapy

Abstract

The examination of cytokine regulation is crucial for predicting the development of irreversible changes in the auditory analyzer that may arise as a consequence of acute sensoneural hearing loss (ASNHL) and for evaluating the efficacy of therapeutic interventions. The baseline level of vascular endothelial growth factor (VEGF-A) in the blood of healthy individuals was found to be 0.89 (0.6; 2.7) ng/ml, with a minimum value of 0.30 ng/ml and a maximum of 32.8 ng/ml. In the course of our study, it was observed that the level of the studied indicator in patients with ASNHL were almost 10 times higher than those in healthy individuals. In Group 1, consisting of patients with ASNHL who received a combination of complex therapy and hyperbaric oxygenation (HBO), the VEGF-A level at the time of hospitalization was 310.1 (127.4; 320.5) ng/ml, with minimum and maximum values of 120.5 and 335.8 ng/ml, respectively. In Group 2, comprising patients with ASNHL who underwent complex treatment and intratympanic steroid therapy, the VEGF-A level was 193.2 (152.2; 169.4) ng/ml, with individual variations ranging from 50.8 to 188.2 ng/ml.

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