Abnormal Uterine Bleeding (AUB) is a common gynecological complaint affecting women across various age groups, significantly impacting their quality of life. The diverse etiologies of AUB necessitate a thorough investigation to identify underlying pathologies, particularly those involving the endometrium. This study aims to establish a clinicopathological correlation between different patterns of abnormal uterine bleeding and findings from endometrial histopathology. By analyzing a cohort of patients presenting with AUB, this research will categorize bleeding patterns based on clinical history (e.g., menorrhagia, metrorrhagia, postmenopausal bleeding) and subsequently correlate these patterns with specific histological diagnoses obtained from endometrial biopsies or curettage samples. The study will assess the prevalence of various endometrial pathologies, such as endometrial hyperplasia (simple, complex, atypical), endometrial polyps, endometritis, carcinoma, and hormonal imbalances, across different AUB presentations. Furthermore, it will investigate the diagnostic utility of endometrial sampling in distinguishing between benign and malignant conditions in patients with AUB. The findings of this clinicopathological correlation will provide valuable insights for clinicians in the effective diagnosis, management, and prognostication of patients presenting with abnormal uterine bleeding, thereby optimizing patient care and minimizing unnecessary invasive procedures.

Abnormal Uterine Bleeding (AUB), Endometrial Histopathology, Clinicopathological Correlation

Mishra D, Sultan S. FIGO's PALM-COEIN classification of abnormal uterine bleeding: a clinico-histopathological correlation in Indian setting. Journal of Obstetrics and Gynaecology of India. 2017;67(2):119–125. Available from: https://doi.org/10.1007/s13224-016-0925-8

Khanam N, Khanam N, Goel JK, Verma K, Kulshresthra K. Correlation of Menstrual Abnormalities with Endometrial Histopathology: A Review. Ind. Indian Journal of Public Health Research & Development. 2023;14(2):407–410. Available from: https://doi.org/10.37506/ijphrd.v14i2.19140

Swami YM, Swami MB, Sharma P. Histopathological evaluation of endometrium in pre and postmenopausal uterine bleeding. Indian Journal of Obstetrics and Gynaecology Research. 2015;2(4):264–269. Available from: https://www.ijogr.org/journal-article-file/1028

Doraiswami S, Johnson T, Rao S, Rajkumar A, Vijayaraghavan J, Panicker VK. Study of endometrial pathology in abnormal uterine bleeding. Journal of Obstetrics and Gynaecology of India. 2011;61(4):426–430. Available from: https://doi.org/10.1007%2Fs13224-011-0047-2

Sharma R, Mishra P, Kumar N, Srivastava P. Histomorphological spectrum of endometrial lesion in women presenting with abnormal uterine bleeding: a 3-year study at a tertiary care center. Tropical Journal of Pathology & Microbiology. 2018;4(7):525–531. Available from: https://doi.org/10.17511/jopm.2018.i07.08

Sajitha K, Shetty PK, Shetty JK, Prasad HLK, Permi HS, Hegde P. Study of histopathological patterns of endometrium in abnormal uterine bleeding. CHRISMED Journal of Health and Research. 2014;1(2):76–81. Available from: https://doi.org/10.4103/2348-3334.134265

Mukhopadhyay I, Rao PS, Nataraj S, Biswas M. An analysis of endometrial bleeding patterns in perimenopausal women. International Journal of Reproduction, Contraception, Obstetrics and Gynecology. 2017;6(7):2776–2783. Available from: https://doi.org/10.18203/2320-1770.ijrcog20172534

Samal R, Vaithy A, Shanmugasamy, Habeebullah S. Clinicopathological analysis of abnormal uterine bleeding in reproductive and postmenopausal women in a tertiary care centre of south eastern part of India. Indian Journal of Obstetrics and Gynecology Research. 2020;7(1):66–70. Available from: https://doi.org/10.18231/j.ijogr.2020.014

Dwivedi SS, Bajpai M, Bhushan I, Satkirti A. Spectrum of endometrial lesions observed on histopathological examination of endometrial samples in women with abnormal uterine bleeding. International Journal of Research in Medical Sciences. 2019;7(11):4124–4128. Available from: https://doi.org/10.18203/2320-6012.ijrms20194978

Vani BS, Vani R, Bai JP. Histopathological evaluation of endometrial biopsies and curetting’s in abnormal uterine bleeding. Tropical Journal of Pathology and Microbiology. 2019;5(4):190–197. Available from: https://doi.org/10.17511/jopm.2019.i04.02

Behera B, Mohanty SR, Patro MK, Mishra DP. Histopathological evaluation of endometrium in cases of abnormal uterine bleeding - an institutional experience in a tertiary care center. Journal of Evidence-Based Medicine and Healthcare. 2020;7(1):24–28. Available from: https://doi.org/10.18410/jebmh/2020/6

Chhatrasal C, Shelgaonkar G, Kulkarni V, Ghanghoria S, Yadav A, Aggarwal P. Evaluation of endometrial histopathological patterns in abnormal uterine bleeding: a study of 1545 cases. International Journal of Medical Science and Public Health. 2017;6(7):1240–1243. Available from: http://dx.doi.org/10.5455/ijmsph.2017.0511619052017

Sharma S, Makaju R, Shrestha S, Shrestha A. Histopathological findings of endometrial samples and its correlation between the premenopausal and postmenopausal women in abnormal uterine bleeding. Kathmandu University Medical Journal (KUMJ). 2014;12(48):275–278. Available from: https://doi.org/10.3126/kumj.v12i4.13734

Bharani V, Rai B, Rajwanshi A, Gupta N, Dey P, Kalra J, et al. Evanescence of endometrial carcinomas in hysterectomy specimens: observations on the "vanishing cancer" phenomenon. International Journal of Surgical Pathology. 2019;27(1):43–47. Available from: https://doi.org/10.1177/1066896918783581