Clinicopathological Correlation of Abnormal Uterine Bleeding Patterns with Endometrial Histopathology

Abstract

Abnormal Uterine Bleeding (AUB) is a common gynecological complaint affecting women across various age groups, significantly impacting their quality of life. The diverse etiologies of AUB necessitate a thorough investigation to identify underlying pathologies, particularly those involving the endometrium. This study aims to establish a clinicopathological correlation between different patterns of abnormal uterine bleeding and findings from endometrial histopathology. By analyzing a cohort of patients presenting with AUB, this research will categorize bleeding patterns based on clinical history (e.g., menorrhagia, metrorrhagia, postmenopausal bleeding) and subsequently correlate these patterns with specific histological diagnoses obtained from endometrial biopsies or curettage samples. The study will assess the prevalence of various endometrial pathologies, such as endometrial hyperplasia (simple, complex, atypical), endometrial polyps, endometritis, carcinoma, and hormonal imbalances, across different AUB presentations. Furthermore, it will investigate the diagnostic utility of endometrial sampling in distinguishing between benign and malignant conditions in patients with AUB. The findings of this clinicopathological correlation will provide valuable insights for clinicians in the effective diagnosis, management, and prognostication of patients presenting with abnormal uterine bleeding, thereby optimizing patient care and minimizing unnecessary invasive procedures.