Clinical And Laboratory Features And Their Correlation In Children With Bronchial Asthma In The Post-Covid Period

Khalmatova Barno Turdikhodjaevna; Tashmatova Gulnoza A’loyevna

doi:10.37547/ijmsphr/Volume06Issue09-06

Authors

Khalmatova Barno Turdikhodjaevna

Professor, Department of Clinic discipline, Kimyo international university in Tashkent, Uzbekistan

https://orcid.org/0000-0001-6982-1243
Tashmatova Gulnoza A’loyevna

Associate of Professor, Department of children’s diseases, Tashkent state medical university, Tashkent, Uzbekistan

https://orcid.org/0000-0002-4384-3767

Keywords

Bronchial asthma children COVID-19

Abstract

The COVID-19 pandemic has significantly altered the clinical course of many chronic pathologies. Despite the relatively mild course of infection in the majority of children, in the post-COVID period patients with bronchial asthma increasingly demonstrate persistent functional impairments, immune imbalances, and biochemical shifts, which may affect disease severity, the frequency of exacerbations, and the effectiveness of baseline therapy. The aim of the study is to identify clinical and laboratory features and their correlation in children with bronchial asthma in the post-COVID period. Materials and methods of research. For the purpose of a comprehensive assessment of the immune status in children suffering from bronchial asthma (BA) who had previously contracted coronavirus infection, a clinical and laboratory study was conducted, involving 135 children aged 7 to 15 years. All patients were under observation in pediatric inpatient and outpatient settings, which ensured the reliability and completeness of clinical data collection. Depending on the history of COVID-19, the examined children were divided into two main groups: Group I – 60 children with a confirmed diagnosis of bronchial asthma of varying severity (mild, moderate, severe) who had a documented history of COVID-19. Group II – 65 children with bronchial asthma of comparable severity who had not contracted coronavirus infection. Results and discussion: An average correlation r=+0.57 was found between the duration of wheezing and K+, while a weak correlation with Ca++ was found (r= -0.37). The correlation between the frequency of exacerbations per year and Ca++ was r=-0.42, but a strong correlation was found with K+ (r= +0.8) and P (r=+0.71). The revealed changes show that there is a direct correlation between the clinical manifestation of bronchial asthma and ME (potassium and phosphorus), which can aggravate the course of the disease. The correlation between Phosphorus and Potassium was positive in all groups, and in severe bronchial asthma the coefficients were higher (r=0.78 and r=0.65, respectively). Zinc in all children, regardless of the severity of the disease, had a pronounced negative correlation, which increased as bronchial asthma worsened (from - r=0.68 for mild asthma to r=-0.88 for severe asthma). A study of the relationship between magnesium and calcium also revealed a negative correlation, particularly pronounced in children with severe asthma. Eosinophils and IgE in children with severe asthma and COVID-19 showed a moderate positive correlation (r=0.36). Conclusion. Thus, the identified changes in the level of ME confirm their significance in the pathogenesis of bronchial asthma, especially in conditions of viral infection, and can be considered as additional markers of the severity of the condition and the effectiveness of therapeutic interventions.

Downloads

Download data is not yet available.

References

1

Aldakheel F. M. Allergic diseases: a comprehensive review on risk factors, immunological mechanisms, link with COVID-19, potential treatments, and role of allergen bioinformatics //International journal of environmental research and public health. – 2021. – Т. 18. – №. 22. – С. 12105.

2

Boechat J. L. et al. COVID-19 and pediatric asthma: clinical and management challenges //International journal of environmental research and public health. – 2021. – Т. 18. – №. 3. – С. 1093.

3

Chang T. M. et al. Asthma control associated with anxiety and depression in asthmatic children following post‐acute COVID‐19 //Pediatric Allergy and Immunology. – 2024. – Т. 35. – №. 6. – С. e14168.

4

da Silva Alves C., Baptista Pestana R., Morais-Almeida M. Recent insights into the impacts of COVID-19 on pediatric asthma //Expert Review of Clinical Immunology. – 2024. – Т. 20. – №. 11. – С. 1347-1366.

5

Di Riso D. et al. Psychosocial impact of Covid-19 outbreak on Italian asthmatic children and their mothers in a post lockdown scenario //Scientific Reports. – 2021. – Т. 11. – №. 1. – С. 9152.

6

Esmaeilzadeh H. et al. Persistent cough and asthma-like symptoms post COVID-19 hospitalization in children //BMC infectious diseases. – 2022. – Т. 22. – №. 1. – С. 244.

7

Ramadan S. et al. Pre and post‐COVID 19 infection pulmonary functions in children with chronic respiratory disease: A case series //Respirology Case Reports. – 2023. – Т. 11. – №. 1. – С. e01077.

8

Su P., Jiang C., Zhang Y. The implication of infection with respiratory syncytial virus in pediatric recurrent wheezing and asthma: knowledge expanded post-COVID-19 era //European Journal of Clinical Microbiology & Infectious Diseases. – 2024. – Т. 43. – №. 3. – С. 403-416.

9

Vasichkina E. et al. COVID-19 heart lesions in children: clinical, diagnostic and immunological changes //International Journal of Molecular Sciences. – 2023. – Т. 24. – №. 2. – С. 1147.

10

Votto M. et al. Safety of biological therapy in children and adolescents with severe asthma during the COVID-19 pandemic: a case series //Acta Bio Medica: Atenei Parmensis. – 2022. – Т. 93. – №. Suppl 3. – С. e2022053.