Odontogenic inflammatory diseases (OIDs) represent a major cause of emergency admissions and are often complicated by deep fascial infections and systemic involvement. Progression to systemic inflammatory response syndrome (SIRS), sepsis, and multiple organ dysfunction (MOD) poses significant threats to patient outcomes. This study synthesizes prognostic indicators, biomarkers, and optimized therapeutic strategies based on an analysis of 91 clinical cases and the development of a predictive digital algorithm. Emphasis is placed on cytokine predictors, systemic infection markers, microbiological dynamics, and differentiated therapy including G-CSF Filgrastim. The findings demonstrate substantial improvements in early detection, prevention of MOD, and overall treatment outcomes.

Odontogenic inflammatory disease, sepsis, filgrastim

Seppänen L, Rautemaa R, Lindqvist C, Lauhio A. Deep neck infections: An upward trend and changing characteristics. J Oral Maxillofac Surg. 2010;68(10):2324–2331. doi:10.1016/j.joms.2009.09.043

Ghali S, Shanti RM, Kanumuri P, Palmer O. Odontogenic infections: A comprehensive review of pathophysiology, diagnosis, and management.

Oral Maxillofac Surg Clin North Am. 2017;29(4):465–473.

doi:10.1016/j.coms.2017.06.003

Zirk M, Buller J, Goedderz A, Kreppel M. Odontogenic deep neck infections: A single-center study of 63 cases. Oral Surg Oral Med Oral Pathol Oral Radiol. 2016;121(3):301–306. doi:10.1016/j.oooo.2015.10.022