Background. Myomatous nodes can impair embryo implantation, alter blood supply to the endometrium, cause an inflammatory response and lead to a decrease in the effectiveness of assisted reproductive technologies (ART). Material and methods. A total of 106 patients with uterine myoma and infertility were examined and divided into 3 groups: 1-group consisted of 35 patients who received drug therapy, 2-group - 32 patients who underwent uterine artery embolization, and 3-group - 39 patients after myomectomy. Conclusion. The choice of the treatment method should take into account the individual characteristics of the patient and her reproductive plans. The frequency of pregnancy after ART varies depending on the method of myoma treatment. Drug therapy - 22.8%, EMA - 12.5%, the best indicators were noted after myomectomy - 30.7%.

Uterine myoma, infertility, assisted reproductive technologies (ART)

Yang Q. et al. Comprehensive review of uterine fibroids: developmental origin, pathogenesis, and treatment //Endocrine reviews. – 2022. – Т. 43. – №. 4. – С. 678-719.

Pritts, E. A., Parker, W. H., & Olive, D. L. (2009). Fibroids and infertility: an updated systematic review of the evidence. Fertility and Sterility, 91(4), 1215–1223. DOI: 10.1016/j.fertnstert.2008.01.051

Fortin, C. N., et al. (2019). Effects of myomas and myomectomy on assisted reproductive technology outcomes. Journal of Gynecology Obstetrics and Human Reproduction, 48(9), 751–755. — PubMed: PMID 31077869

Freytag, D., et al. (2021). Uterine fibroids and infertility. Diagnostics, 11(8), 1455. DOI: 10.3390/diagnostics11081455

Manyonda, I. T., et al. (2020). Uterine-artery embolization or myomectomy for uterine fibroids. The New England Journal of Medicine, 383(5), 440–451. DOI: 10.1056/NEJMoa1914735

Kalampokas, T., et al. (2016). Ulipristal acetate for uterine fibroids: a systematic review and meta-analysis. Gynecological Endocrinology, 32(2), 91–96. DOI: 10.3109/09513590.2015.1106471

Şükür Y. E., Saridogan E. Multiple myomectomy to aid fertility treatment-surgical and fertility outcomes: a retrospective cohort study //Facts, views & vision in ObGyn. – 2021. – Т. 12. – №. 4. – С. 283.

Ajayi, A. B., et al. (2019). Fibroid and assisted reproductive technology. Journal of Clinical Obstetrics Gynecology Infertility, 3(1), 1040.

De Milliano, I., et al. (2017). Endometrial changes during ulipristal acetate use: A systematic review. European Journal of Obstetrics & Gynecology and Reproductive Biology, 214, 56–64.

Donnez, J., Donnez, O., & Dolmans, M.-M. (2016). Safety of treatment of uterine fibroids with ulipristal acetate. Expert Opinion on Drug Safety, 15(12), 1679–1686.

Donnez, J., et al. (2015). Efficacy and safety of repeated use of ulipristal acetate in uterine fibroids. Fertility and Sterility, 103(2), 519–527. DOI: 10.1016/j.fertnstert.2014.10.038

Dolmans, M.-M., et al. (2021). Intramural myomas more than 3–4 cm should be surgically removed before in vitro fertilization. Fertility and Sterility, 116(4), 945–958. DOI: 10.1016/j.fertnstert.2021.08.016

Donnez, J., & Dolmans, M.-M. (2020). Hormone therapy for intramural myoma-related infertility: From ulipristal acetate to GnRH antagonist. Reproductive Biomedicine Online, 41(3), 431–442.

Yu, H., et al. (2023). Conservative surgical treatment of uterine fibroids in women of childbearing age. European Journal of Gynaecological Oncology, 44(4).

Ahmad A., Kumar M., Bhoi N.R., Badruddeen, Akhtar J., Khan M.I. et al. Diagnosis and management of uterine fibroids: current trends and future strategies. J. Basic Clin. Physiol. Pharmacol. 2023; 34(3): 291-310. https://dx.doi.org/10.1515/jbcpp-2022-0219

Young M., Mikes B. Uterine fibroid embolization //StatPearls. – 2025.

Aninye I.O., Laitner M.H. Uterine fibroids: assessing unmet needs from bench to bedside. J. Womens Health (Larchmt). 2021; 30(8): 1060-7. https://dx.doi.org/10.1089/jwh.2021.0280