The Use Of Nanochitosan For Local Prophylaxis Of Postoperative Infections In Hip Arthroplasty: An Experimental Study

Asilova S.U; Mahsudov SH.A.; Nazarova F. N.; Kuziev G.A

doi:10.37547/ijmsphr/Volume07Issue01-09

Authors

Asilova S.U

Kimyo international University in Tashkent and Tashkent State Medical University, Uzbekistan
Mahsudov SH.A.

Kimyo international University in Tashkent and Tashkent State Medical University, Uzbekistan
Nazarova F. N.

Kimyo international University in Tashkent and Tashkent State Medical University, Uzbekistan
Kuziev G.A

Kimyo international University in Tashkent and Tashkent State Medical University, Uzbekistan

Keywords

Nanochitosan hip arthroplasty postoperative infection

Abstract

This experimental study evaluates the effectiveness of nanochitosan as a local prophylactic agent against postoperative infections following hip arthroplasty. The investigation included assessment of inflammatory and immunological biomarkers such as C-reactive protein (CRP), procalcitonin, interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), ferritin, and white blood cell counts in animal models. Results demonstrate that nanochitosan significantly reduces markers of systemic inflammation and infection compared to traditional prophylactic methods. The findings suggest that nanochitosan coatings on implants may provide a promising strategy for preventing periprosthetic joint infections, thereby improving postoperative outcomes and reducing complications.

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