Clinical Significance Of The C-786t Polymorphism Of The Nos3 Gene In Purulent-Necrotic Lesions Of The Lower Extremities Associated With Diabetes Mellitus

Abstract

Purulent-necrotic lesions of the lower extremities developing against the background of diabetes mellitus are currently considered one of the most pressing problems of modern medicine. These complications are characterized by high rates of disability and limb amputation. In recent years, the role of genetic factors in the development of this pathology has gained particular importance.

In the present study, a comparative analysis of the genotype frequency distribution of the C-786T polymorphism of the NOS3 gene was conducted among patients with diabetes-associated purulent-necrotic foot lesions who underwent surgical or conservative treatment. The results demonstrated that the unfavorable C/C genotype of the NOS3 gene was more frequently observed in patients who required surgical treatment, whereas the wild-type T/T genotype may be associated with a milder course of the disease and better effectiveness of conservative therapy. The C-786T polymorphism of the NOS3 gene may serve as a significant genetic marker for predicting purulent-necrotic complications developing in patients with diabetes mellitus.