A marker of mesenchymal cells, vimentin, with high and moderate expression is present in both epithelial and stromal cells with “eosinophilic” forms of polyps and only in the stroma of patients with “neutrophilic” polyps. The presence of high expression of vimentin indicates high activity of mesenchymal cells. In prognostic terms, these changes indicate future relapses. Identification of the CD68 marker; its low and moderate expression ¬may indicate a low participation of macrophages in the formation of nasal polyps of both forms. The presence of single stained cells in mesenchymal accumulations indicates low phagocytic activity. High and moderate expression of CD45 in -mesenchymal accumulations located in “eosinophilic” polyps confirms our assumption that these mesenchymal accumulations are the “growth zone” of formations. High and moderate expression of CD138 in mature epithelial ¬cells in all tissue samples of both forms of polyps and the absence of expression of this marker in clusters of mesenchymal formations, as well as average expression in cells located in the stroma, possibly indicate the origin of the latter from active mesenchymal cells. In the “eosinophilic form” of polyps, moderate and high expression of CD34 is detected. These results confirm our assumption about the formation of a new vascular system in mesenchymal -accumulations. A well-developed vascular system is also observed near the epithelium and in the stroma. An increase in the number of vessels is ¬a sign of relapse, and an increase ¬in the number of newly formed vessels is prognostically ¬unfavourable and indicates the occurrence of a relapse.

Nasal polyp, cytokines, marker

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