Necrotizing dermatitis is a heterogeneous group of skin lesions characterized by pro-gressive necrosis of the dermis and/or subcutaneous tissue against the background of infectious, autoimmune or vasculopathic genesis. This condition is associated with a high risk of systemic complications, disability and death, especially with untimely diagnosis and tactical errors in treatment. The article discusses modern clinical and pathogenetic forms of necrotizing dermati-tis, including necrotizing fasciitis, pyoderma gangrenous, necrotizing vasculitis and other rare syndromes. Particular attention is paid to the algorithms of differential diagnosis, the role of laboratory and imaging methods, as well as an interdisciplinary approach to treatment, taking into account the etiology of the disease. The review is based solely on English-language publi-cations of recent years and aims to summarize the most clinically relevant data for dermatolo-gists, surgeons, and intensive care professionals.

Necrotizing dermatitis, necrotizing fasciitis, pyoderma gangrenous

Stevens D.L., Bryant A.E. Necrotizing soft-tissue infections // N. Engl. J. Med. – 2017. – Vol. 377, No. 23. – P. 2253–2265.

Schwameis M., Auer J., Steiner M.M. et al. Management of necrotizing soft tis-sue infections: literature review // Eur. Surg. – 2020. – Vol. 52. – P. 89–98.

Lancerotto L., Tocco I., Salmaso R. et al. Necrotizing fasciitis: classification, di-agnosis, and management // J. Trauma Acute Care Surg. – 2012. – Vol. 72, No. 3. – P. 560–566.

Wong C.H., Khin L.W., Heng K.S. et al. The LRINEC (Laboratory Risk Indicator for Necrotizing Fasciitis) score: a tool for distinguishing necrotizing fasciitis from other soft tissue infections // Crit. Care Med. – 2004. – Vol. 32, No. 7. – P. 1535–1541.

Dworkin M.S., Westercamp M.D., Park L., McIntyre A. The epidemiology of ne-crotizing fasciitis including factors associated with death: a review of the litera-ture // Epidemiol. Infect. – 2005. – Vol. 132, No. 5. – P. 1–7.

Kohli-Pamnani D., Saavedra A. Neutrophilic dermatoses: a review and update // Clin. Dermatol. – 2019. – Vol. 37, No. 6. – P. 505–516.

Gupta D., Sheth S., Payette M. Necrotizing neutrophilic dermatoses: case series and literature review // J. Am. Acad. Dermatol. – 2019. – Vol. 81, No. 1. – P. 187–197.

Bodansky H.J., Ferguson C.J., Johnston G.A. Necrobiosis lipoidica and other ne-crotizing skin diseases // Clin. Exp. Dermatol. – 2015. – Vol. 40, No. 5. – P. 438–444.

Jha P., Das S., Vasudevan B., Badwal S. Necrotizing fasciitis and its mimics: a review // Indian J. Dermatol. – 2013. – Vol. 58, No. 6. – P. 519–525.

Vaiman M., Lazarovitch T., Heller L., Lotan G. Risk factors for mortality in pa-tients with necrotizing fasciitis // Ear Nose Throat J. – 2015. – Vol. 94, No. 8. – P. E1–E4.